Vitamins
Vitamin B6 (Pyridoxine)
Also known as: pyridoxine, B6, pyridoxal phosphate, PLP
A water-soluble B vitamin used in protein metabolism and neurotransmitter synthesis. Oral B6 is first-line for pregnancy nausea; extra IV B6 for energy is unproven.
Medically reviewed by Akash Bhagat, DO, FACEP
What the evidence supports
| Use | Evidence |
|---|---|
| Correcting vitamin B6 deficiency | Established |
| Nausea and vomiting of pregnancy (oral B6 is the studied form) | Established |
| Energy or mood via IV in people without deficiency | Unproven |
Common side effects
- Injection-site soreness
- Nausea
- Sensory tingling with very high long-term doses
Who should be cautious or avoid this
- Chronic high doses can cause sensory neuropathy
- Parkinson's medications (levodopa without carbidopa)
- Some antiepileptic drugs lower B6 status
What it is
Vitamin B6 (pyridoxine) is a cofactor for more than 100 enzymes, including those that make serotonin, dopamine, and GABA and that metabolize amino acids. It is one of the vitamins in a typical B-complex mix and is sometimes listed on its own — for example in pregnancy-oriented drips.
Why it’s used in IV therapy
Added to nausea, energy, and “mother” formulas. Oral B6 (often with doxylamine) is a standard treatment for morning sickness; some clinics put pyridoxine in an IV instead.
What the evidence says
Correcting deficiency is established. For pregnancy nausea, the evidence base is oral B6, which ACOG lists as first-line. There isn’t comparable trial evidence that an IV dose works better than a tablet for that indication — it’s a convenience, not a proven upgrade. Extra B6 for energy in well-nourished people is unproven.
Side effects and cautions
Water-soluble and usually well tolerated at drip doses. Very high daily intake over months can damage sensory nerves (numbness, tingling). Tell the clinician about Parkinson’s or seizure medications.