How to Choose an IV Therapy Clinic: 12 Questions to Ask
A practical checklist for vetting an IV therapy clinic or mobile service — credentials, screening, sourcing, emergency readiness, and red flags.
Read guideMedications
Prescription onlyOndansetron (Zofran)
Also known as: Zofran, anti-nausea medication
A prescription anti-nausea drug common in hangover and illness drips. Effective — with a heart-rhythm caution.
Medically reviewed by Akash Bhagat, DO, FACEP
What the evidence supports
| Use | Evidence |
|---|---|
| Nausea and vomiting | Established |
Common side effects
- Headache
- Constipation
- Dizziness
- Fatigue
Who should be cautious or avoid this
- Long QT syndrome or heart-rhythm disorders
- Other medications that prolong QT
- Low potassium or magnesium
- Serotonin-affecting medications (rare serotonin syndrome)
What it is
Ondansetron is a prescription medication that blocks serotonin receptors involved in nausea and vomiting. It’s widely used in hospitals, emergency rooms, and urgent care.
Why it’s used in IV therapy
Added to hangover, food-poisoning, and stomach-bug drips to stop nausea quickly.
What the evidence says
Ondansetron is an established, effective anti-nausea drug. When people feel dramatically better after a “hangover IV,” this ingredient often deserves much of the credit.
Side effects and cautions
Headache and constipation are common. It can affect heart rhythm (QT prolongation), so clinicians should ask about heart conditions and other medications first. Because it’s a prescription drug, it should only be added after a clinician reviews your history.