Coenzymes

NAD+ (Nicotinamide Adenine Dinucleotide)

Also known as: NAD, NAD+ IV, NAD infusion

A coenzyme central to cellular energy that declines with age. Intriguing lab research; human evidence for IV NAD+ is early.

Medically reviewed by Akash Bhagat, DO, FACEP

· Published by NeuMed Modern Urgent Care + IV Therapy

What the evidence supports

UseEvidence
Anti-aging / longevity Limited
Energy and mental clarity Limited
Addiction recovery support Limited

Common side effects

  • Chest tightness or pressure during infusion
  • Nausea
  • Abdominal cramping
  • Flushing
  • Headache

Who should be cautious or avoid this

  • Must be infused slowly — side effects are rate-related
  • Pregnancy and breastfeeding (not studied)
  • Heart conditions — discuss chest symptoms with a physician
  • Long chair times (often 1–4+ hours)

What it is

NAD+ is a coenzyme found in every cell. It’s essential for converting nutrients into energy and for DNA-repair enzymes. NAD+ levels decline with age, which has made it a focus of longevity research.

Why it’s used in IV therapy

Clinics offer NAD+ infusions for energy, focus, “cellular repair,” and anti-aging, and some for addiction-recovery support.

What the evidence says

Animal studies of raising NAD+ are genuinely interesting. Human research is much earlier, and most of it studies oral precursors (NR, NMN) rather than IV NAD+. There’s limited evidence about how much infused NAD+ reaches cells or what lasting effects it has. Treat NAD+ IV as an experimental wellness service — and be wary of anyone presenting it as proven anti-aging.

Side effects and cautions

NAD+ is famous for uncomfortable side effects if infused too fast: chest tightness, nausea, and cramping. A good clinic runs it slowly and adjusts the rate. Expect a long appointment and a higher price than other drips.

IV vs. injection vs. oral: subcutaneous NAD+ injections and oral precursors are cheaper alternatives; none has strong human outcome data yet.

See how NeuMed offers this in Houston

Sources

  1. Rajman L, Chwalek K, Sinclair DA. Therapeutic Potential of NAD-Boosting Molecules. Cell Metab. 2018

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